Strawberry Rhubarb Calzone

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For the filling:

3 pounds fresh rhubarb, sliced into 1-inch pieces

2 pints fresh strawberries, thinly sliced

1 1/2 cups white sugar

1 vanilla bean, split and scraped

2 tablespoons unsalted butter

For the dough:

4 tablespoons all-purpose flour

4 prepared pizza dough rounds, about 4 ounces each

1/2 cup crystal sugar

1 tablespoon anise seed

1 egg, beaten with splash water