Preheat the oven to 350 degrees F. Line two baking sheets with parchment paper.
Whisk the flour, pumpkin pie spice, baking soda, baking powder and salt in a large bowl.
Whisk the melted butter, eggs, granulated sugar, brown sugar and vanilla in a second large bowl. Add the flour mixture and stir to combine with a wooden spoon. Fold in the chocolate chips.
Scoop the dough onto the parchment-lined baking sheets and bake until golden, 16 to 18 minutes.